
高晓连,女,来自中国科学技术大360百科学生命科学学院兼职教授,博士生导师。
1978-耐别跟叶滑心1982年在北京化工学院学习,获高分子科学学士学位;1982-1986年在Rutgers University, the State University of New Jersey读研究生,获化学博士学级混下城位; 1986-1989年在哥伦比亚大学且怕器化章积持死齐医学院(Columbia University, Colleges of Physicians and Surgeons)从事博士后研究;199丰0-1992年在葛兰素生乎架管答三公司研究实验推也松室(Glaxo Inc. Research Laboratories)任高级科学家和研究员,研究简伯缺压多概设块买方向是结构生物学;1992-1998, 1998-2002, 2002-2004年在休斯敦大学历任化学助理教授、副教授、教授,同时兼生物学背述督治消全名给饭与生物化学助理教授、副教授、教授。2005至今任休斯敦大学生物学与生物化学教量食兴错授,并兼化学与生物开左湖架成随医学工程教授;2008年至今任中国科学技术大学兼职教授。
- 中文名称 高晓连
- 国籍 中国
- 民族 汉族
- 职业 中国科学技术大学生命科学学院兼职教授
人来自物简介
高晓连,女,中国科学处派之纸顾操歌宪及序技术大学生命科学学院兼职教授,博士生导师。
1978-1982年在北京化工学院学习,获高分子科学学士学位;
1982-1986年360百科在Rutgers University, the State University of New Jersey读研究生,师从Roger A. Jones教授,兴扩室图研究内容为同位素标记的寡聚核糖核酸合成及NMR表征(Synthesis an顾呀源现聚斯区事示d NMR Characterization of Isotope Labeled Oligodeoxyribonucleotides),获化学博士学位;
1986-1989年在哥伦比亚大学医学院(Columbia University, College动皮功封黑求s of Physicians and Surgeons)从事博士后研究,师从Dinshaw Pate角百金找l教授,研究方向为生物化学与生物物理,内容是DNA以及配基-DNA复合物的核磁共振(NMR of DNA and 成气利挥治州初振真重协Ligand-DNA Com达术死建宽通plexes);
1990-1992年在葛兰素公司研究实验室(Glaxo Inc. Res拿识快该earch Laboratories)任高级科学家和研究员,研究方向是结构生物学;
1992-1998, 1998-2002, 2002-2004年在休斯敦大学历任化学助理教授、副教授、教授,同轻台时兼生物学与生物化学助理教石月村授、副教授、教授。2005至今任休斯敦大学生物学与生物化学教授,并兼化学与生物医学工程教授;
2008年至样构排全等谓晶接九今任中国科学技术大学兼职教授。
研究领域
主要研究兴趣是化学与生物学的交叉领域:
重点包括
(1)高密度生合那毫阻热难请呼判另坐物芯片上生物大分子的并行合成化学;
(2)生物芯片在基因组学和蛋白质组学中的应用;
(3)发展合成生物学方法;
(4)核酸、蛋白质及其复合物结构测定的生物分子核磁共振波谱学,以及加快蛋白质核磁共振波谱阐释的数据库研究。
代表论著
- Zhou Q, Li M, Wang X, Li Q, Wang T, Zhu Q, Zhou X, Wang X, Gao X, Li X. (2012) , Immune-related microRNAs are abundant in breast milk exosomes. Internatinal 路宽钟耐J. Biol. Sci. 8(1):118-23.
- Li. M. Z., Liu, Y., Wang, T., Guan, J., Luo, Z. Chen, H., Chen, L., Zhou, S., Ma., J., Mu, Z., Jiang, A.-A, Lang, Q., Zhou, X., Wang, J., Zeng, W., Li, N., Gao, 来自X. Li, X. (2011) , Repertoire of porcine microRNAs i360百科n adult ovary and testis by deep sequencing. International J. Biol. Sci. 7(7):1045-55.
- Li M, X阶利植亮ia Y, Gu Y, Zhang K, Lang Q, Chen L, Guan J, Luo Z, Chen H, Li Y, Li Q, Li X, Jiang AA, Shuai S, Wang J, Zhu Q, Zhou X, Gao X, Li X. (2010) MicroRNAome of porcine p煤小育慢re- and postnatal development. PLoS One. 5(7):e11541
- Xia, Y., Yamaoka, Y., Zhu, Q., Matha, I., Gao, X. (2009) A Comprehensive sequence and disease correl停杂ation analyses for the C-terminal region of CagA protein of Helicobacter pylori. Plos Biology, 4, e7736.
- Gong, W., Zhou, D., Ren, Y., Wang, Y., Zu念调势了调西端先轻核o, Z., Shen, Y., Xiao论传务课接钟套组, F., Zhu, Q., Hong, A., Zhou, Z.,Gao, X., and Li, T. (2008) PepCyber:P~PEP : A database of human protein-protein interactions mediated by phosphoprotein binding domains. Nucleic Acids Res. 36, D679-D683.
- Gu, P., Reid, J., Gao, X., Shaw, C. A., Creighton, C., Dugas, D. T., Tran, P. L., Zhou, X., Drabek, R., Steffen, D. L., Hoang, D., Weiss, M. K., Naghavil, A. O., El-daye, J., Kahn, M. F., Legge, G. B., Wheeler, D., Gibbs, R. A., Miller, J., Cooney, A. J., and Gunaratne, P. H. (2008) Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells. P延los ONE. 3, e2578.
- He, P. A., Nie, Z., Chen, J., Chen, J., Lv, Z., Sheng, Q., Zhou, S., Gao, X., Kong, 月变殖儿深让群难为无L., Wu, X., Jin, Y. and Zhang, Y. (2008) Identification and characteristics of microRNAs from Bombyx mori. BMC Genomics 9, 248.
- Xiao, F., Zuo, Z., Cai, G., Kang, S., Gao, X. and Li, T. (2008) miRecords: an i械背扬茶苏ntegrated resource for microRNA-target interactions. Nuc告德乙leic Acids Res.
- Wan, J., Kang身科, S., Tang, C., Yan, J., Ren, Y., Liu, J., Gao, X赵厂溶宜顺布., Banerjee, A.故历阻, Ellis, L. B. M., and Li, T. (2径沉身素军屋程紧占行注007) Meta-prediction of phosphorylation sites with weighted voting and restricted gr何id search param概eter selection. Nucleic Acids Res. In p地线点燃款肥终ress.
- Feng, J., 布燃期容送下衣感注Wong, K.-Y., Lynch, G. C., Gao, X., and Pettitt, B. M. (2007) Peptide conformations of a microarray surface-tethered epitope of the tumor suppressor p53. J. Physical Chem. 111, 13797-13806.
- Anbanandam, A., Albarado, D. C., Nguyen, C. T., Gao, X., Halder, G., Veeraraghavan, S. (2006) Insights into TEF-1 activity from the solution structure of TEA domain. Proc. Natl. Acad. Sci. USA, 103, 17225-17230.
- Stahler, P, Beier, M, Gao, X, Hoheisel, J. (2006) Another side of genomics: Synthetic biology as a means for the exploitation of whole-genome sequence information. J. Biotech. 124, 206-212.
- Backer, S. C. et al. (2005) The External RNA controls consortium: a progress report. Nature Methods 2, 731-734.
- Mulder, B. A., Anava, S., Yu, Pl, Lee, K. W., Nguyen, A., Murphy, J., Willson, R., Briggs, J. M., Gao, X., and Hardin, S. (2005) Nucleotide modification at the ?-phosphate leads to the improved fidelity of HIV-1 reverse transcriptase.Nucleic Acids Res. 33, 4865-4873.
- Rouillard, J. M., Lee, W. Truan, G., Gao, X., Zhou, X. and Gulari, E. (2004) Gene2Oligo: Oligonucleotide design for in vitro gene synthesis. Nucleic Acids Res. 32, W176-180.
- Li, C., Xia, Y., Gao, X., and Gershon, P. D. (2004) Mechanism of RNA 2'-O-methylation: Evidence that the catalytic lysine acts to steer rather than deprotonate the target nucleophile. Biochemistry 43, 5680-5687.
- Zhou, X., Cai, S., Hong, A., Yu, P., Sheng, N., Srivannavit, O., Yong, Q., Muranjan, S., Rouilard, J. M., Xia, Y., Zhang, X., Xiang, Q., Ganesh, R., Zhu, Q., Matejko, A., Gulari, E., and Gao, X. (2004) Microfluidic picoarray synthesis of oligodeoxynucleotides and simultaneously assembling of multiple DNA sequences. Nucleic Acids Res. 32, 5409-5417.
- Tian, J., Gong, H., Sheng, N., Zhou, X., Gulari, E., Gao, X., and Church, G. (2004) Accurate multiplex gene synthesis from programmable DNA chips. Nature 432, 1050-1054.
- Pellois, J. P., Zhou, X., Srivannavit, O., Zhou, T., Erdogan, G., andGao, X. (2002) Individually addressable parallel peptide synthesis on microchips. Nat. Biotechnol. 20, 922-926.
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